Medically reviewed by C.H. Weaver M.D. Medical editor 6/2022
Chemotherapy is any treatment involving the use of drugs to kill cancer cells. Cancer chemotherapy may consist of single drugs or combinations of drugs, and can be administered through a vein, injected into a body cavity, or delivered orally in the form of a pill.
Chemotherapy may be combined with precision cancer medicines or immunotherapy - together these are all considered "systemic" therapy.
Systemic therapy is different from surgery or radiation therapy in that the cancer-fighting drugs circulate in the blood to parts of the body where the cancer may have spread and can kill or eliminate cancers cells at sites great distances from the original cancer. As a result, chemotherapy is considered a systemic treatment.
More than half of all people diagnosed with cancer receive systemic therapy. For millions of people who have cancers that respond well to chemotherapy, this approach helps treat their cancer effectively, enabling them to enjoy full, productive lives. Furthermore, many side effects once associated with chemotherapy are now easily prevented or controlled, allowing many people to work, travel, and participate in many of their other normal activities while receiving chemotherapy.
Understand the Goals of Systemic Therapy
The goals of treatment with systemic treatment with chemotherapy, immunotherapy, and precision cancer medicines will depend largely on the type and stage of your cancer. If you’re currently undergoing or about to begin treatment you may want to understand the goals of your prescribed therapy.
The three main goals of treatment with systemic therapy, as determined by cancer type and stage, are:
- To cure the cancer
- To control the cancer
- To relieve symptoms caused by the cancer
Depending again on the type and stage of your cancer, you may be receiving chemotherapy alone or in combination with other therapies as well as before or after another treatment. The goals of administering chemotherapy before (neoadjuvant) or after (adjuvant) another treatment are as follows:
- Neoadjuvant chemotherapy may be administered before surgery or radiation therapy. In either case, the goal of chemotherapy is to shrink the tumor and allow the next treatment to be more effective. This entails shrinking a tumor to make it more easily and completely removed by surgery or more effectively treated with radiation.
- Adjuvant chemotherapy may be administered after surgery or radiation. Once a cancer has been treated with surgery or radiation, it’s possible that undetectable stray cancer cells remain in the patient’s body. Chemotherapy may then be administered with the goal of destroying or preventing the growth of these stray cells.
How is Systemic Therapy given
Chemotherapy can be given:
- Intravenously (IV),
- By mouth in the form of a pill,
- With a shot (injection), or
- By intrathecal and intraventricular injection (meaning into the spinal fluid surrounding the spinal cord or brain).
Many types of chemotherapy can be given at home. Through instruction, you and your family members can learn how to administer chemotherapy in pill form or by injection with small syringes and needles similar to those that people with diabetes use to administer insulin. In some cases, a nurse will administer chemotherapy in an outpatient clinic. In other cases, it may be necessary to go to the hospital to receive treatment.
Chemotherapy is typically given in cycles, which is a treatment followed by a period of rest. A cycle can last one or more days, but is usually one, two, three, or four weeks long. A course of chemotherapy is comprised of multiple cycles. Each course is different, but generally consists of four to six cycles. It may take a relatively short period of time to receive some chemotherapy drugs, while others take hours. It all depends on the treatment regimen that your doctor recommends.
If your chemotherapy is given through an IV, your doctor may suggest an implanted venous access device (VAD) such as a Hickman® catheter or Port-a-Cath. VADs are surgically placed in a large vein near the heart and can stay in place for long periods of time. By using a VAD, you will not have to have smaller catheters repeatedly placed in your arm veins.
How often will I receive treatment?
Generally, treatments are given daily, weekly, or monthly. How often you receive chemotherapy depends on the type of cancer and which drug or combination of drugs you receive. Your doctor will help you determine the most effective treatment schedule for you. Chemotherapy is usually given in cycles with rest periods between each administration.
Chemotherapy may be used in combination with surgery. When chemotherapy is given before surgery it is referred to as neoadjuvant chemotherapy. The goal of neoadjuvant chemotherapy is to shrink the cancer before it is surgically removed. If the chemotherapy is given after surgery, it is referred to as adjuvant chemotherapy. The goal of adjuvant chemotherapy is to kill any cancer cells left in the body after surgery. Regardless of whether it is given before or after surgery, chemotherapy will still be administered in cycles that depend on the type of cancer and which drug or combination of drugs.
What Systemic Therapy will I receive?
You will receive therapy that is best suited to achieve your goals of treatment. When selecting a treatment or treatments, your doctor will consider:
- Your diagnosis
- Whether cancer driving mutations can be targeted
- How far along your cancer is in its development
- The expected behavior of the cancer
- Where the cancer originated
- Your age
- Other medical problems you may have
- Any potential side effects from the treatment.
Your treatment may consist of chemotherapy or precision cancer medicines or immunotherapy.
How is my Therapy scheduled?
Therapy is typically given in cycles, which is a treatment followed by a period of rest. A cycle can last one or more days, but is usually one, two, three or four weeks long. A course of chemotherapy is comprised of multiple cycles. Each course is different, but generally consists of four to six cycles. The actual administration of the chemotherapy drugs may take minutes to several hours, depending on the drug or drugs given.
If your chemotherapy is given through an IV, your doctor may suggest an implanted venous access device (VAD) or Port-a-Cath. VADs are surgically placed in a large vein near the heart and can stay in place for long periods of time. By using a VAD you will not have to have smaller catheters repeatedly placed in arm veins.
How often will I receive therapy?
Chemotherapy drugs are typically given in cycles. The cycle consists of the day(s) the drug is administered followed by a rest and recovery period. A cycle usually lasts one to four weeks and is then repeated, which means a treatment is administered every one to four weeks. Each course of chemotherapy is different, but generally consists of four to six cycles. The actual administration of some chemotherapy drugs may take only seconds or minutes, while others may take hours or even days.
What are the advantages and disadvantages of oral chemotherapy drugs?
In the past, chemotherapy drugs were mainly administered into a vein (intravenous). Recently, oral chemotherapy drugs are being developed. Oral drugs may provide greater ease of administration since patients can take them at home rather than going to a clinic or hospital for treatments. Not all chemotherapy drugs are available in oral form. Furthermore, intravenous (IV) administration is sometimes preferable because the doctor can be more certain that the patient received the appropriate dose as scheduled and they can monitor the patient during administration.
What is a venous access device (VAD) and what types are used for cancer patients?
A VAD is a surgically implanted device that provides long-term access to a major vein. Although there are several different types of VADs, the two most commonly used for cancer treatment and taking blood samples are:
- Tunneled external catheters (Hickman® catheter), or
- Subcutaneous implanted ports (port-a-cath).
Both a Hickman® catheter and a port-a-cath are surgically implanted into a major vein. For the Hickman® catheter, the plastic tube or catheter is attached to a major vein and then comes out of the body for external access. A port-a-cath is implanted completely beneath the skin into a major vein under the collarbone. The port may then be accessed by a special needle through the skin to deliver chemotherapy, hydration, transfusions, and for taking blood samples.
The following are some key features that distinguish these two types of VADs:
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- Easier insertion, removal, and access
- Higher flow capacity due to single, double, or triple lumen (channel)
- Fewer device-related infections
- Fewer activity restrictions
- Less day-to-day maintenance
- Lower flow capacity due to only single or double lumen (channel)
Patients undergoing very demanding therapies that require frequent treatment, blood transfusions, and nutritional support—such as a stem cell transplant—may be required a Hickman® catheter instead of a port.
Who needs a VAD?
Not every chemotherapy patient requires a VAD. For some chemotherapy treatment plans, the inconvenience of implanting and accessing a VAD may outweigh the benefits. You may wish to ask your doctor if a VAD is an appropriate option for you, especially if you experience any of the following:
- You are extremely anxious about having needles inserted.
- Your veins are difficult to access or become inaccessible.
- You must have alternative veins in your foot or hand accessed, which may be associated with more discomfort.
- You are undergoing continuous infusion chemotherapy (over an hour).
- You anticipate many months of chemotherapy treatments.
- You are receiving intravenous chemotherapy that requires multiple needle sticks.
- Your treatment requires frequent drawing of blood samples.
- Your treatment strategy involves chemotherapy agents that may cause “vein pain” when administered through the arm.
- You have a physician or nurse who recommend a vascular access device.
Will chemotherapy make me sick?
Without receiving special anti-nausea medications, most patients will experience some nausea after treatment with chemotherapy. Nausea and vomiting may last 24-48 hours. The severity of nausea and vomiting mainly depends on which chemotherapy drugs were used. A number of very effective medications called anti-emetics or anti-nausea drugs are now available to help lessen or prevent nausea and vomiting. These medications may be given to you intravenously during your chemotherapy, or you may be given a prescription medication to take at home.
Will Immunotherapy make me sick?
Side effects associated with immunotherapy can be different than those associated with chemotherapy. Know what to watch for...
What tests will be performed?
Your doctor determines what kinds of tests are needed. If you are receiving chemotherapy, you may have blood work done anywhere from the day of or up to 7 days before your scheduled treatment. This blood work will include a complete blood count (CBC), chemistry profile, and any necessary cancer markers. A blood sample for a complete blood count (CBC) will also be collected seven to fourteen days following your chemotherapy. It is important to be aware of possible symptoms of reduced red blood cell (RBC), white blood cell (WBC), or platelet (PLT) production. Be sure to report any of the following:
- Fever (over 101º F), congestion, or a cold.
- A rash, blister, easily bruised skin, signs of bleeding, an infected cut, itching or burning in the genital area.
- Weakness, fatigue, or shortness of breath.
Why is my complete blood count (CBC) tested after treatment?
Chemotherapy destroys rapidly dividing cells, a characteristic of cancer cells. However, red blood cells, white blood cells, and platelets also divide rapidly and are frequently damaged by chemotherapy. Your red blood cell count, white blood cell count, and platelet count may all go down. Your doctor monitors these counts to determine the toxicity of treatment and to predict your risk for complications, as well as to plan future therapy.
- For more information, see section on Understanding Your Blood Counts
Will I lose my hair because of my treatment?
Hair loss occurs with some, but not all, chemotherapy drugs. The amount of hair loss varies from a slight thinning to complete baldness and affects the scalp, eyelashes and eyebrows, legs, armpits, and pubic area.
Hair loss will typically begin two or three weeks after your first treatment. The amount of hair that you lose will depend on the type of chemotherapy drug you are taking. Hair typically begins to grow back approximately 2-3 weeks after treatment is finished. The hair may grow back differently than it was before treatment. For example color or texture (curly or straight) may be different.
Remember that hair loss associated with chemotherapy is temporary and the hair WILL grow back. In the meantime, here are a few tips to help you cope with the loss:
- You may wish to cut your hair before it starts falling out. The experience of losing the hair is sometimes worse than dealing with it once it’s gone. If you expect to lose all or a lot of your hair, cutting it first may be easier to cope with.
- Plan ahead; shop for a wig before your hair is gone, especially if you wish to match your natural color. Or, take this opportunity to try something different.
- Try hats or head scarves; these are good alternatives or a compliment to a wig.
- Remember to cover your head or use sunscreen on your scalp. Skin that has been covered with hair may be particularly sensitive to UV rays of the sun.
- Ask your insurance company if they cover the cost of the wig.
- Treat your new hair gently once it grows back. Avoid chemicals, bleach, peroxide, or colors.
What are the side effects of chemotherapy
Chemotherapy works by destroying cancer cells; unfortunately, it cannot tell the difference between a cancer cell and a healthy cell. The delivery of cancer therapy often affects the body’s normal tissues or organs that are not affected by cancer. Side effects, or complications of treatment are the undesired consequence of affecting normal cells.
Side effects of treatment may cause inconvenience, discomfort, and occasionally even fatality to patients. Additionally and perhaps more importantly, side effects may prevent delivery of the full dose of chemotherapy on schedule. This is extremely important to understand since your expected outcome from chemotherapy is based on delivering treatment at the full dose and schedule prescribed in the treatment plan Because the expected outcome from therapy is based on delivering treatment at the prescribed dose and schedule, a change from the treatment plan may reduce your chance of achieving an optimal outcome. . This is extremely important to understand. In other words, side effects not only cause discomfort and unpleasantness, but may also compromise your chance of cure by preventing the delivery of therapy at its optimal dose and time.
The most common side effects of chemotherapy are low blood counts, nausea, vomiting, hair loss, and fatigue. Some side effects may be temporary and merely annoying. Others, such as infection or a low white blood count, can be life-threatening. For example, one of the most serious potential side effects of chemotherapy is a low white blood cell count – a condition called neutropenia (new-truh-pee-nee-ah) – which can put you at risk for severe infections or treatment interruptions.
Fortunately, last 20 years has brought a great deal of progress in the development of treatments to help prevent and control the side effects of cancer therapy. These developments have
- Led to vast improvements in the management of symptoms associated with cancer treatment
- Allowed for greater accuracy and consistency concerning the administration of cancer treatment
- Made many cancer treatments more widely available to patients throughout the world.
When to Call Your Doctor
The development of any of the following symptoms during your chemotherapy treatment may indicate a serious condition. If you experience any of the following throughout your cancer treatment, please inform your doctor.
- Fever higher than 101º F
- Shaking chills
- Vomiting that continues 48 hours after treatment
- Bleeding or bruising
- Shortness of breath/chest pain
- Severe constipation or diarrhea
- Painful or frequent urination
- Blood in the urine or stool
- Soreness, redness, swelling, pus, or drainage at your VAD site
- Irregular or rapid heart beat
- Pain in a new place.
- Pain that is not relieved by your pain medication.
- Headache that is not relieved by Tylenol®
- Inability to eat and continued weight loss
- Mouth sores
- Nasal congestion, drainage, cough
- One or more of the following symptoms in conjunction with repetitive diarrhea or vomiting (signs of dehydration): Dry, cracked lips Dry, sticky tongue Increased thirst Decreased urination Increased weakness Increased pulse rate
- Dizziness/lightheadedness (especially when rising to a standing position)
Why am I so tired?
Many people who receive chemotherapy experience fatigue. Fatigue has many causes but frequently occurs because of anemia caused by the chemotherapy. Your daily activities should be planned according to how you feel, and you should take rest periods throughout the day as often as you feel necessary. Anemia can be effectively treated.