New Breakthrough May Advance Triple Negative Breast Cancer Treatment

Cancer Connect

Could Targaprimir-96 be the Next TNBC Treatment?

by Dr. C.H. Weaver M.D. 8/1/2018

Scientists at The Scripps Research Institute have developed a new drug candidate that lowers the growth rate of tumor cells in animal models1 in one of the most difficult cancers to battle: triple negative breast cancer. This is the first time that scientists have been able to take a genetic sequence and design a drug candidate that is effective against this type of cancer. What makes the molecule so unique is its ability to destroy only the cancer cells that express the cancer gene, leaving healthy cells intact. The research is poised to totally change the way we identify drugs: by working with the genetic makeup of an illness.

The compound designed by the scientists is called Targaprimir-96; it causes breast cancer cells to destroy themselves by targeting a specific RNA that sparks the cancer precisely. In the past, scientists were forced to test millions of possible drug candidates to find a few that successfully affected target areas. The new study makes the process much speedier and more effective. It relies on an approach called Inforna, which is centered on creating compounds that bind to RNA folds. They are particularly effective at targeting microRNAs.

MicroRNAs are a recently discovered class of non-coding RNAs2 that play an important role in regulating gene expression. They typically work as ‘dimmer switches’ for genes, binding to their transcripts and interfering with the protein production process. In the new study, the new compound was tested on animals over a 21-day period. Results showed lesser production of microRNA-96 (which promotes cancer by stopping programmed cell death from occurring) and increased programmed cell death. Because the compound was so precise in its targets, healthy cells were left intact. Scientists expressed that in the future, this strategy might be used to treat other harmful RNAs, which lead to everything from aggressive cancers to powerful viruses such as Ebola and Zika.


Copyright © 2018 CancerConnect. All Rights Reserved.

Comments (1)
mary john
mary john

ALL THANKS TO DR OSO WITH HIS HERBAL PORTION I WAS COMPLETELY CURED FROM BREAST CANCER. I’m here again to appreciate. DR OSO God will always continue to bless you more abundantly, for the good works you don in my life, I will always keep on writing good and posting my testimonies about you on the Internet, I’m MARY JOHNSON from TEXAS . I was tested breast cancer positive, I saw a blog on how DR OSO cured people with his herbal portion, i did not believe in natural medicine but i just decided to give him a try, I contacted him,and explain my situation to him,few day later he sent me the herb, after taking DR OSO herbal medicine for few weeks i went to hospital for check up so luckily i was healed with his herbal portion, i am so happy. If you have any type of cancer problem or you are also infected with any kind of disease, contact him or call/whatapp +2348162084839 for advice and for his product,i hope this testimony also help some one out there .. here is the dr website. His blog page you can also email me for more info about DR oso via ALL THANK TO DR OSO... ...................................... ....

Triple Negative Breast Cancer