Biomarker May Help Improve Treatment of Triple-Negative Breast Cancer

Interleukin-13 receptor alpha 2 (IL13Ralpha2), biomarker appears active in the growth and spread of TNBC

Interleukin-13 receptor alpha 2 Biomarker May Help Improve Treatment of Triple-Negative Breast Cancer

by Dr. C.H. Weaver M.D. 9/1/2017

Known as interleukin-13 receptor alpha 2 (IL13Ralpha2), the biomarker may help doctors identify patients at high risk of disease spread and potentially provide a target for treatment. These findings were reported in Breast Cancer Research.

The majority of breast cancers are hormone receptor-positive, meaning that the cancer cells are stimulated to grow from exposure to the female hormones estrogen and/or progesterone. Other breast cancers are referred to as HER2-positive, which means that they overexpress the human epidermal growth factor receptor 2, a biologic pathway that is involved in replication and growth of a cell.

Breast cancers, on the other hand, that are not stimulated to grow from exposure to estrogen or progesterone and do not overexpress HER2 (HER2 negative) are called triple-negative breast cancers. Triple-negative breast cancers tend to be more aggressive than other breast cancers and have fewer treatment options because hormonal therapies that target hormone receptors or HER2 are ineffective.

Because patients with triple-negative breast cancer have limited treatment options, finding effective therapies is an important area of research. In a recent study, researchers sought to understand more about how these cancers grow and spread and find targets they could use for treatment of this type of disease. Namely, they investigated genes that help triple-negative breast cancer spread.

To identify potential drivers of growth in triple-negative breast cancer and targets for treatment, the researchers used different laboratory tests to find genes involved in the growth of breast cancer tumors that spread to the lungs (metastasis). Specifically, they looked at the role of the protein (or biomarker) IL13Ralpha2 in breast tumor growth and spread.

According to the study’s findings, triple-negative and metastatic breast cancer tumors were more likely to overexpress IL13Ralpha2 than other types of breast tumors. In addition, patients with higher IL13Ralpha2 levels were more likely to develop breast cancer metastasis compared with those with lower levels.

This association between IL13Ralpha2 and tumor metastasis in triple-negative breast cancer can potentially be applied to treatment. Using mice, the researchers found that when they reduced levels of IL13Ralpha2 in metastatic cancer cells, the primary tumor didn’t grow quite as quickly and lung metastasis was significantly reduced.

Based on these findings, IL13Ralpha2 might help advance the treatment of triple-negative breast cancer. The protein may help doctors identify patients at risk for cancer spread and also be an effective target for therapy to prevent metastasis.

Reference: Papageorgis P, Ozturk S, Lambert AW, et al. Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis. Breast Cancer Research. 2015 July 25;17(1):98. doi: 10.1186/s13058-015-0607-y.

Copyright © 2015 CancerConnect. All Rights Reserved.

Comments (1)
No. 1-1
mary john
mary john

ALL THANKS TO DR OSO WITH HIS HERBAL PORTION I WAS COMPLETELY CURED FROM BREAST CANCER. I’m here again to appreciate. DR OSO God will always continue to bless you more abundantly, for the good works you don in my life, I will always keep on writing good and posting my testimonies about you on the Internet, I’m MARY JOHNSON from TEXAS . I was tested breast cancer positive, I saw a blog on how DR OSO cured people with his herbal portion, i did not believe in natural medicine but i just decided to give him a try, I contacted him,and explain my situation to him,few day later he sent me the herb, after taking DR OSO herbal medicine for few weeks i went to hospital for check up so luckily i was healed with his herbal portion, i am so happy. If you have any type of cancer problem or you are also infected with any kind of disease, contact him drosohaberhome@gmail.com or call/whatapp +2348162084839 for advice and for his product,i hope this testimony also help some one out there .. here is the dr website. https://sites.google.com/view/drosohaberhome/ His blog page https://drosohaberhome.blogspot.com you can also email me for more info about DR oso via maryjohnson9700@gmail.com ALL THANK TO DR OSO... .............................