Side Effects of Cancer Treatment Photosensitivity

Photosensitivity or the tendency to sunburn easily can occur with certain chemotherapy drugs.

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by Dr. C.H. Weaver M.D. updated 4/2023

Many drugs cause photosensitivity, including some chemotherapy drugs. Protecting your skin from the sun is very important. If you should get a severe sunburn, treatment is aimed at reducing inflammation and relieving pain.

  • What is photosensitivity?
  • What causes photosensitivity?
  • What are the symptoms of photosensitivity?
  • What is the treatment for photosensitivity?
  • What else can I do?

What is photosensitivity

Photosensitivity is an enhanced skin response to ultraviolet radiation (sunlight). This means that you may sunburn easily. A sunburn that you got within a week before chemotherapy may reappear, or rarely, a sunburn may spread to skin that was not exposed to the sun.

What causes photosensitivity

There are many drugs that may cause photosensitivity. Chemotherapy drugs commonly associated with photosensitivity include:

  • dacarbazine (DTIC-Dome®)
  • fluorouracil (5-FU)
  • methotrexate
  • vinblastine (Velban®)

What are the symptoms of photosensitivity

If you are photosensitive, you will sunburn easily. Symptoms of a sunburn include:

  • Redness
  • Inflammation
  • Blistering
  • Weeping
  • Peeling

What is the treatment for photosensitivity

The treatments for a rash that results from photosensitivity aim to reduce inflammation and relieve pain.

Corticosteroid cream: Steroids work by reducing inflammation. Your doctor may prescribe a corticosteroid cream that you rub on the rash.

Analgesics: These over-the-counter medications can relieve pain associated with a rash. Examples are acetaminophen (Tylenol®) or aspirin.

What else can I do?

It is very important to protect your skin from the sun by following these tips:

  • Wear long sleeves and long pants.
  • Wear a wide brimmed hat.
  • Wear light, cotton gloves.
  • Use sunscreen on the skin that you cannot cover.
  • Sunblock with physical barrier such as zinc oxide may be necessary for vulnerable areas, such as the hands and nose.

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