Heartburn - GERD - Reflux and Cancer Treatment

Cancer and its treatment can be associated with GERD "reflux" Here is what you need to know and what to do about it.

by Dr. C.H. Weaver M.D. 8/2019

Many people with cancer experience acid reflux or "heartburn", a burning pain in the chest. Other symptoms such as a persistent sore throat, a consistently hoarse voice, a regular cough, or choking when lying down at night all suggest "reflux" or what doctors call gastroesophageal reflux disease (GERD)

What is heartburn?

Heartburn is an irritation of the esophagus which causes burning discomfort in the chest just behind the breastbone. Heartburn can occur in association with eating certain foods or taking certain drugs, including chemotherapy drugs.

The burning sensation results when harsh stomach juices come in contact with and irritate the delicate lining of the esophagus, which is the tube-like structure that connects the mouth to the stomach.

What causes heartburn?

Heartburn is caused when harsh stomach juices come in contact with and irritate the delicate lining of the esophagus, which is the tube that connects the mouth to the stomach. Stomach juices help break down food in the stomach and contain a strong acid, called hydrochloric acid. While the stomach is naturally protected from the harmful qualities of acid, the esophagus is not.

Stomach juices come into contact with the esophagus when the muscle that separates the stomach from the esophagus, called the lower esophageal sphincter, does not work properly. When working normally, this muscle works like a natural valve, letting food into the stomach but keeping stomach juices out of the esophagus. When not functioning properly, this muscle relaxes and allows stomach juices to flow upward into the esophagus. Your doctor may call this backward movement of stomach juices gastroesophageal reflux. The hydrochloric acid damages the lining of the esophagus causing heartburn and its associated symptoms.

What are the symptoms of heartburn?

Heartburn may feel like:

  • A burning chest pain that begins at the breastbone that moves up toward the throat
  • Food or liquid is coming back into the mouth or throat
  • An acid or bitter taste at the back of the throat
  • A worsening pain/burning behind the breastbone when lying down or bending over

How can heartburn be prevented?

In general, there are a number of lifestyle changes that you can make to prevent or lower your risk of experiencing heartburn. These may include:

  • Stop smoking
  • Limit or eliminate alcohol
  • Limit your caffeine intake (coffee, soda, tea)
  • Lose some weight if you are overweight
  • Avoid fatty foods (deep fried foods)
  • Do not eat 2-3 hours before going to bed
  • Avoid foods that cause you to have heartburn

How is heartburn treated?

Avoiding things that cause heartburn can help, but if lifestyle changes are not enough to prevent heartburn, your doctor may prescribe medication. Effective over-the-counter and prescription medications are available.

Over the counter antacids: Antacids work by neutralizing the acid in your stomach. They may contain the following compounds alone or in combination: calcium carbonate, aluminum hydroxide, magnesium hydroxide and magaldrate. Examples are Maalox®, Mylanta®, Rolaids®, or Tums®.

H2 blockers: These medications decrease stomach acid by blocking histamine from binding to the H2 receptors on cells in the stomach lining. Histamine, a natural substance produced by the body, stimulates cells in the stomach lining to release acid into the stomach. H2 blockers decrease gastric acid secretions. A few examples of these drugs that may be prescribed include cimetidine (Tagamet®), famotidine (Pepcid®), nizatidine (Axid®) or ranitidine (Zantac®). Pepcid® and Zantac® are now available over the counter.

Proton-pump inhibitor: These medications inhibit the final step in the production of gastric acid. Examples include omeprazole (Prilosec®), lansopraxole (Prevacid®), esomeprazole (Nexium®), pantoprozole (Protonix®) or rabeprazole (Aciphex®). If it is determined that an ulcer is the underlying cause of your heartburn, these medications may be prescribed for short-term treatment of the ulcer. However, an ulcer is caused by the H. pylori bacteria and must be treated with a combination of medication and antibiotics for long-term results.

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