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Class: Other Generic

Generic Name: Oxybutynin

Trade Names: Ditropan XL®, Oxytrol®, Gelnique®

How is Gelnique used? Gelnique is used to treat overactive bladder with symptoms of a strong need to urinate right away; leaking accidents due to a strong, immediate need to urinate; or a need to urinate often.

What is the mechanism of action? Gelnique acts by relaxing the bladder muscles. It is a type of drug known as an anticholinergic.

How is Gelnique given (administered)? Depending on the form of the medicine that is prescribed, Gelnique is taken orally (by mouth), administered to the skin in the form of a patch, or administered to the skin as a gel.

How are patients monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with Gelnique.  Patients may undergo physical examinations or other measures to assess side effects and response to therapy.

What are the most common side effects of treatment with Gelnique?

  • Dry mouth
  • Skin reactions to gel or patch

What are some of the less common side effects of treatment with Gelnique?

  • Trouble emptying the bladder
  • Increased risk of stomach problems in some patients
  • Headache, dizziness, sleepiness
  • Worsening of myasthenia gravis
  • Swelling (angioedema)
  • Heat prostration in hot environments (Gelnique can decrease sweating)

This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.

Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.

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What can patients do to help alleviate or prevent discomfort and side effects?

  • Pay careful attention to the physician’s instructions, and discuss side effects with your physician.
  • Do not drive or operate heavy machinery until you know how Gelnique affects you.
  • Avoid alcohol. It may increase the risk of serious side effects.

Are there any special precautions patients should be aware of before starting treatment?

  • Oxybutynin should not be taken by people who have trouble emptying their bladder, slow emptying of the stomach, uncontrolled narrow-angle glaucoma, or allergies to any of the ingredients in oxybutynin.
  • Patients should inform their physician about all medical conditions, including stomach or intestinal problems, constipation, weak urine stream or trouble emptying the bladder, narrow-angle glaucoma, kidney problems, liver problems, gastric reflux disease, or myasthenia gravis.
  • Patients should inform their physician of any other medication or supplement they are taking (whether prescription or over-the-counter), including bisphosphonates and anticholinergics.
  • Patients should tell their doctor if they are pregnant, breastfeeding, or planning to become pregnant. It is not known whether oxybutynin will harm an unborn baby.

When should patients notify their physician?

Tell your doctor if you experience any side effects that bother you or don’t go away. Seek immediate medical care if you notice signs of a serious allergic reaction, such as swelling of the face, lips, throat, or tongue.

What is a package insert?

A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers.  A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.

Important Limitations of Use

The information provided above on the drug you have selected is provided for your information only and is not a substitute for consultation with an appropriate medical doctor.  We are providing this information solely as a courtesy and, as such, it is in no way a recommendation as to the safety, efficacy or appropriateness of any particular drug, regimen, dosing schedule for any particular cancer, condition or patient nor is it in any way to be considered medical advice. Patients should discuss the appropriateness of a particular drug or chemotherapy regimen with their physician.

As with any printed reference, the use of particular drugs, regimens and drug dosages may become out-of-date over time, since new information may have been published and become generally accepted after the latest update to this printed information.  Please keep in mind that health care professionals are fully responsible for practicing within current standards, avoiding use of outdated regimens, employing good clinical judgment in selecting drugs and/or regimens, in calculating doses for individual patients, and verifying all dosage calculations.

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CANCERCONNECT SPECIFICALLY DISCLAIMS AND EXCLUDES ALL EXPRESSED OR IMPLIED WARRANTIES, INCLUDING ANY IMPLIED WARRANTIES AS TO QUALITY, ACCURACY (INCLUDING TYPOGRAPHICAL ERRORS), MERCHANTABILITY, OR FITNESS FOR ANY PARTICULAR PURPOSE OF THE INFORMATION CONTAINED HEREIN.  CANCERCONNECT DISCLAIMS ALL LIABILITY OR DAMAGES ARISING FROM ANY USE OF THE INFORMATION.

The prescribing physician is solely responsible for making all decisions relating to appropriate patient care including, but not limited to, drugs, regimens, dose, schedule, and any supportive care.