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Class: Anti-seizure drug-nerve pain (also called anti-convulsant)

Generic Name: Pregabalin

Trade Name: Lyrica®

For which conditions is Lyrica approved for? Lyrica is approved for the treatment of adult patients with the following conditions:

  • Fibromyalgia (pain all over your body)
  • Pain from damaged nerves (neuropathic pain) that happens with diabetes or that follows healing of shingles, spinal cord injury
  • Partial seizures when taken together with other seizure medicines

What is the mechanism of action? Lyrica is believed to help control pain or seizures by calming damaged or overactive nerves that cause these conditions. Lyrica is thought to work by binding to a protein that’s involved in overactive nerves and reducing the activity of the protein.

How is Lyrica typically given (administered)? Lyrica is a pill that you take by mouth. Depending on the condition for which you’re being treated, your doctor will tell you how much Lyrica to take and when to take it.

How are patients typically monitored? Lyrica can increase your risk of suicidal thoughts or behavior. Your doctor will monitor you for worsening depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.

What are the common (occur in 30% or more of patients) side effects of treatment with Lyrica?

  • Dizziness

What are the less common (occur in 10% to 29% of patients) side effects of treatment with Lyrica?

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  • Infection
  • Sleepwalking
  • Weight gain
  • Loss of full control of bodily movements
  • Blurred vision
  • Double vision
  • Constipation
  • Headache
  • Dry mouth
  • Fatigue
  • Peripheral edema

This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.

Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.

What can patients do to help alleviate or prevent discomfort and side effects?

  • Pay attention to any changes you experience—especially sudden changes in mood, behaviors, thoughts, or feelings.
  • Make sure you go to all your scheduled doctor visits.
  • Call your doctor between visits if you are worried about symptoms.
  • Take Lyrica exactly as your doctor tells you.

Are there any special precautions patients should be aware of before starting treatment?

  • If you experience suicidal thoughts or actions, stop taking Lyrica immediately—even if you haven’t talked to your doctor yet.

When should patients notify their physician?

  • Stop taking Lyrica and call your doctor right away if you have any of these signs of a serious allergic reaction: swelling of your face, mouth, lips, gums, tongue, throat or neck; trouble breathing; rash, hives (raised bumps); or blisters.
  • Call a doctor right away if you experience any of the following: thoughts about suicide or dying or attempt to commit suicide new or worse depression new or worse anxiety feel agitated or restless panic attacks trouble sleeping (insomnia) new or worse irritability are acting aggressive, being angry, or violence are acting on dangerous impulses an extreme increase in activity and talking (mania) any other unusual changes in behavior or mood

What is a package insert?

A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.