Generic Name: cabazitaxel
Trade Name: Jevtana®
How is Jevtana used? Jevtana is used in combination with prednisone (a steroid medication) for the treatment of hormone-refractory, metastatic prostate cancer. Previous treatment must have included Taxotere® (docetaxel).
What is the mechanism of action? Jevtana belongs to a group of drugs referred to as microtubule inhibitors. Jevtana produces its anticancer effects by causing abnormalities in microtubule formation in cells. Microtubules are components of cells that provide structural framework that enables cells to divide and grow. The abnormal microtubule formation caused by Jevtana inhibits cellular replication.
How is Jevtana given (administered)? Jevtana is given as an intravenous (IV) infusion, usually every three weeks. The prednisone that is used in combination with Jevtana is taken every day by mouth.Prior to each infusion of Jevtana, patients receive additional medications to reduce the likelihood of a severe allergic reaction.
How are patients monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with Jevtana. Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems, such as the kidneys or liver. Patients may also undergo physical examinations, scans or other measures to assess side effects and response to therapy.
What are the most common (occur in 10% or more of patients) side effects of treatment with Jevtana?
- Low blood cell counts
- Weakness, lack of energy
- Abdominal Pain
- Blood in the urine
- Back pain
- Loss of appetite
- Pain, numbness, or tingling in your hands or feet
- Shortness of breath
- A change in your sense of taste
- Joint pain
- Hair loss
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
- Pay careful attention to the physician’s instructions and inform the physician of any side effects.
- Take oral prednisone as prescribed.
- Maintain adequate rest and nutrition.
- If possible, avoid large crowds or people who are sick or not feeling well, as this drug may leave some patients susceptible to infection.
- Wash hands often to reduce the risk of infection.
- Eat small meals frequently to help alleviate nausea.
- Avoid activities that may cause injury or bruising.
- Use a soft toothbrush and an electric razor to prevent cuts on the mouth or skin.
Are there any special precautions patients should be aware of before starting treatment?
- Patients should inform their physician of any other medication they are taking (whether prescription or over-the-counter, including vitamins, herbs, etc.) as they may interact with treatment.
- Patients should inform their physician if they are pregnant, breastfeeding or planning a family in the near future.
- Patients should inform their physician about all medical conditions, including kidney or liver problems.
- Patients should inform their physician about prior allergic reactions.
When should patients notify their physician?
Tell your doctor if you experience any unusual symptoms. Notify your healthcare provider immediately if you experience blood in your urine or symptoms of infection such as fever, cough, burning on urination, or muscle aches. Also notify your doctor or nurse right away if you experience symptoms of an allergic reaction during or soon after treatment with Jevtana. Symptoms of an allergic reaction include rash or itching, skin redness, feeling dizzy or faint, breathing problems, chest or throat tightness, or swelling of the face. Other serious problems to watch for and to discuss with your physician include severe vomiting and diarrhea (which can lead to dehydration and loss of electrolytes) and kidney failure. Signs of kidney failure include swelling of the face or body or a decrease in the amount of urine produced each day.
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Important Limitations of Use
The information provided above on the drug you have selected is provided for your information only and is not a substitute for consultation with an appropriate medical doctor. We are providing this information solely as a courtesy and, as such, it is in no way a recommendation as to the safety, efficacy or appropriateness of any particular drug, regimen, dosing schedule for any particular cancer, condition or patient nor is it in any way to be considered medical advice. Patients should discuss the appropriateness of a particular drug or chemotherapy regimen with their physician.
As with any printed reference, the use of particular drugs, regimens and drug dosages may become out-of-date over time, since new information may have been published and become generally accepted after the latest update to this printed information. Please keep in mind that health care professionals are fully responsible for practicing within current standards, avoiding use of outdated regimens, employing good clinical judgment kin selecting drugs and/or regimens, in calculating doses for individual patients, and verifying all dosage calculations.
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