Frequently Asked Questions About Inqovi® (Decitabine & Cedazuridine Combined)

TraceyS

Generic Name: Decitabine & Cedazuridine Combined

Trade Name: Inqovi®

For which conditions is Inqovi approved for? Inqovi is FDA approved for the treatment of adults with intermediated and high-risk myelodysplastic syndromes (MDS), including chronic myelomonocytic leukemia (CMML).

What is the mechanism of action? Inqovi is a combination of decitabine (Dacogen®) and cedazuridine and is the only orally administered hypomethylating agent approved by the FDA. Inqovi produces its anticancer effects by causing a chemical reaction that damages the DNA in a cell. The DNA damage caused by Inqovi inhibits protein synthesis and results in cellular death.

How is Inqovi typically given (administered)? Inqovi is taken orally. Take Inqovi one time a day as prescribed by your healthcare provider at about the same time each day. Inqovi should be taken whole (do not split or chew) on an empty stomach (do not eat for at least 2 hours before and 2 hours after). If you miss a dose of Inqovi, take your dose as soon as possible if it is within 12 hours of the usual time that; then resume taking Inqovi at your scheduled time. If you miss a dose by more than 12 hours or if you vomit after taking Inqovi, do not take an additional dose and take your next scheduled dose on the following day at your normal time.

How are patients typically monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with Inqovi. Typically, blood will be drawn to monitor levels of blood cells and to monitor functions of some organ systems, such as the kidneys or liver. Patients may also undergo physical examinations, scans, or other measures to assess side effects and response to therapy.

What are the common side effects of treatment with Inqovi?

  • Low blood cell counts
  • Fatigue
  • Constipation
  • Bleeding
  • Muscle pain
  • Mouth sores
  • Joint pain
  • Nausea
  • Shortness of breath
  • Diarrhea
  • Rash
  • Dizziness
  • Fever with low white blood cell count
  • Swelling of extremities
  • Headache
  • Cough
  • Decreased appetite
  • Upper respiratory tract infection
  • Pneumonia
  • Changes in liver function tests

This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.

Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.

What can patients do to help alleviate or prevent discomfort and side effects?

  • Pay careful attention to the physician’s instructions and inform the physician of any side effects.
  • Maintain adequate rest and nutrition.
  • Drink plenty of fluids. (Patients should ask their physician about the amount of liquid to consume during a day.)
  • If possible, avoid large crowds or people who are sick or not feeling well, as this drug may leave some patients susceptible to infection.
  • Wash hands often to reduce the risk of infection.
  • Avoid activities that may cause injury or bruising.
  • Use a soft toothbrush and an electric razor to prevent cuts on the mouth or skin.
  • Eat small meals frequently to help alleviate nausea.
  • If patients have been prescribed an anti-nausea medication, they should be sure to take the prescribed doses.

Are there any special precautions patients should be aware of before starting treatment with Inqovi?

  • Patients should inform their physician if they have kidney problems or liver problems.
  • Patients should inform their physician if they are pregnant, breastfeeding, or planning a family in the near future. This drug may cause birth defects. It is important to use some form of birth control while undergoing treatment.
  • Patients should inform their physician of any other medication they are taking (whether prescription or over-the-counter, including vitamins, herbs, etc.) as they may interfere with treatment.
  • Patients should check with their physician before starting any new drug or nutritional supplement.
  • Patients should inform their physician of any known drug or food allergies or any reactions to medications they have experienced in the past.

When should patients notify their physician?

If they experience:

  • Fever
  • Chills
  • Body aches
  • Bruising more easily than usual

What is a package insert?

A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics, and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.

Important Limitations of Use

The information provided above on the drug you have selected is provided for your information only and is not a substitute for consultation with an appropriate medical doctor. We are providing this information solely as a courtesy and, as such, it is in no way a recommendation as to the safety, efficacy or appropriateness of any particular drug, regimen, dosing schedule for any particular cancer, condition or patient nor is it in any way to be considered medical advice. Patients should discuss the appropriateness of a particular drug or chemotherapy regimen with their physician.

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