Class: Supportive Care
Generic Name: anagrelide (eh-NA-gre-lide)
Trade Name: Agrylin®
For which conditions is Agrylin approved for? Agrylin is FDA approved for the treatment of high blood platelet levels (thrombocythemia) associated with myeloproliferative disease (disease in which higher than normal levels of one or more types of blood cells are produced).
What is the mechanism of action? Agrylin is classified as a phospholipase A2 inhibitor. Agrylin is believed to reduce the number of platelets by blocking the enzyme called phospholipase A2, which is at least partially responsible in the maturation process of platelets.
How is Agrylin typically given (administered)? Agrylin is given orally and may be taken with food or on an empty stomach. The dose may be changed based on the patient’s platelet count.
How are patients typically monitored? Patients will usually have scheduled meetings with their healthcare provider while they are being treated with Agrylin. Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems, such as the kidneys or liver. Patients may also undergo physical examinations, scans or other measures to assess side effects and response to therapy.
During treatment with Agrylin, patients will have their platelet levels closely monitored. Patients will also have their heart function monitored, as Agrylin may cause abnormalities with the pumping action of the heart. Patients experiencing anxiety, cold sweating, increased heart rate, severe pain in the chest and/or the jaw, neck, back, or arms, or shortness of breath should contact their healthcare provider immediately.
What are the common (occur in 30% or more of patients) side effects of treatment with Agrylin?
What are the less common (occur in 10% to 29% of patients) side effects of treatment with Agrylin?
- Heart rhythm abnormalities (palpitations)
- Abdominal pain
- Dizziness, drowsiness
- Difficulty breathing
What are the possible late side effects of treatment with Agrylin? Although uncommon, treatment with Agrylin may cause damage to the heart that affects its pumping action. Patients will be monitored for this condition.
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
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Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
- Pay careful attention to the physician’s instructions and inform the physician of any side effects.
- Wear sunscreen and protective clothing and try to minimize sun exposure.
- Drink plenty of fluids. (Patients should ask their physician about the amount of liquid to consume during a day.)
- Maintain adequate rest and nutrition.
- Eat small meals frequently to help alleviate nausea.
Are there any special precautions patients should be aware of before starting treatment?
- Patients should tell their physician if they are pregnant, breastfeeding or planning a family in the near future. This drug may cause birth defects. It is important to use some kind of birth control while undergoing treatment. Also, patients may want to talk to their physician if they are considering having children in the future, since some drugs may cause fertility problems.
- It is important that patients inform their physician of any pre-existing conditions (chicken pox, infection, heart disease, kidney disease, liver disease, lung disease, thyroid disease, etc.) as they may worsen with this drug.
- Patients should inform their physician if they have ever had convulsions or seizures.
- Patients should inform their physician about any other medication they are taking (whether prescription or over the counter, including vitamins, herbs, etc.) as they may interfere with treatment.
- Patients should check with their physician before starting any new drug or nutritional supplement.
- Patients should inform their physician of any known drug or food allergies or any reactions to medications they have experienced in the past.
- Patients who miss an oral dose should not double up the dose, but instead should contact their physician.
- Aspirin may increase risk of serious hemorrhagic events. Consult your physician.
- Patients should keep tablets out of the reach of children and return any unused tablets to the pharmacy for safe disposal if treatment is terminated.
When should patients notify their physician?
- Anxiety, cold sweats, increased or uneven heart rate, severe pain in the chest and/or the jaw, neck, back, or arms, or shortness of breath
- Persistent or severe headache
- Persistent or severe abdominal pain
- Swelling of face
- Black tarry stools
- Blood in urine
- Unexplained bleeding (bruises, bloody nose)
- Swelling of the feet or ankles
- Sudden weight gain
- Difficulty breathing
- Noticeable changes in heart rate or rhythm
What is a package insert?
A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Important Limitations of Use
The information provided above on the drug you have selected is provided for your information only and is not a substitute for consultation with an appropriate medical doctor. We are providing this information solely as a courtesy and, as such, it is in no way a recommendation as to the safety, efficacy or appropriateness of any particular drug, regimen, dosing schedule for any particular cancer, condition or patient nor is it in any way to be considered medical advice. Patients should discuss the appropriateness of a particular drug or chemotherapy regimen with their physician.
As with any printed reference, the use of particular drugs, regimens and drug dosages may become out-of-date over time, since new information may have been published and become generally accepted after the latest update to this printed information. Please keep in mind that health care professionals are fully responsible for practicing within current standards, avoiding use of outdated regimens, employing good clinical judgment kin selecting drugs and/or regimens, in calculating doses for individual patients, and verifying all dosage calculations.
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