Generic Name: Floxuridine (flocks-YOO-ri-deen)
Trade Name: FUDR®
For which conditions is this drug approved? Floxuridine is FDA approved for the treatment of colon or stomach cancer that has spread to the liver. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA. Patients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physician.
What is the mechanism of action? Floxuridine belongs to a class of agents referred to as antimetabolites. Floxuridine produces its anti-cancer effects through chemical reactions that inhibit the production of DNA, RNA and certain proteins. Inhibiting the synthesis of DNA and RNA stops cellular replication and causes cellular death.
How is floxuridine typically given (administered)? Floxuridine is given into an artery (intra-arterial) often given directly into the hepatic artery, which is the main artery of the liver.
How are patients typically monitored?
Patients will usually have scheduled meetings with their healthcare provider while they are being treated with floxuridine. Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems, such as the kidneys or liver. Patients may also undergo physical examinations, scans or other measures to assess side effects and response to therapy.
What are the common (occur in 30% or more of patients) side effects of treatment with floxuridine?
• Low levels of white blood cells – increases risk of infection
• Low levels of red blood cells – increases risk of anemia
• Low levels of platelets – increases risk of bleeding
• Mouth sores
What are the less common (occur in 10% to 29% of patients) side effects of treatment with floxuridine?
• Nausea and vomiting
• Loss of appetite
• Abnormal liver function levels, as determined by blood tests
• Ulcers of the stomach
• Abdominal pain, heartburn
• Pain, peeling, redness, increased pigmentation, itching, swelling of the palms of the hands or soles of the feet (hand-foot syndrome)
• Hair loss
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What can patients do to help alleviate or prevent discomfort and side effects?
FDA Grants Orphan Drug Designation to LYT-200 for Pancreatic Cancer and being evaluated in Cholangiocarcinoma
Pancreatic Cancer - Cholangiocarcinoma Clinical Trial
• Patients should avoid excessive friction, heat and cold in order to reduce the incidence or severity of hand-foot syndrome.
• Patients should keep the palms of their hands and soles of their feet moisturized in order to reduce the incidence or severity of hand-foot syndrome.
• Pay careful attention to the physician’s instructions and inform the physician of any side effects.
• Maintain adequate rest and nutrition.
• Wear sunscreen and protective clothing and try to minimize sun exposure.
• Drink plenty of fluids. (Patients should ask their physician about the amount of liquid to consume during a day.)
• If possible, avoid large crowds or people who are sick or not feeling well, as this drug may leave some patients susceptible to infection.
• Wash hands often to reduce the risk of infection.
• Eat small meals frequently to help alleviate nausea.
• If patients have been prescribed an anti-nausea medication, they should be sure to take the prescribed doses.
• Avoid activities that may cause injury or bruising.
• Use a soft toothbrush and an electric razor to prevent cuts on the mouth or skin.
• For mouth sores, patients should rinse their mouth three times a day with a salt and soda solution (8 ounces of water mixed with ½ to 1 tsp baking soda and/or ½ to 1 tsp salt) and brush their teeth with a soft toothbrush to help prevent the development of mouth sores
Are there any special precautions patients should be aware of before starting treatment?
• Patients should inform their physician if they are pregnant, breastfeeding or planning a family in the near future. This drug may cause birth defects. It is important to use some kind of birth control while undergoing treatment. Also, patients may want to talk to their physician if they are considering having children in the future, since some drugs may cause fertility problems.
• It is important that patients inform their physician of any pre-existing conditions (chicken pox, heart disease, kidney disease, liver disease, lung disease, etc.) as they may worsen with this drug.
• Patients should inform their physician of any other medication they are taking (whether prescription or over-the-counter, including vitamins, herbs, etc.) as they may interfere with treatment.
• Patients should check with their physician before starting any new drug or nutritional supplement.
• Patients should inform their physician of any known drug or food allergies or any reactions to medications they have experienced in the past.
When should patients notify their physician?
• Yellowing of skin or eyes
• Mouth sores
• Fever, chills, cough, sore throat, flu or cold-like symptoms
• Signs of infection – redness, swelling, pus, tenderness
• Persistent or severe fatigue
• Unexplained or excessive bleeding (nosebleeds, bruising, black tarry stools, blood in the urine, etc.)
• Persistent or extreme diarrhea
• Persistent or extreme nausea or vomiting
• Severe abdominal pain or stomach pain
• Heartburn or chest pain
• Severe pain, peeling, swelling, redness of palms of hands or soles of feet
• Skin rash, hives, itching
What is a package insert? A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.
Copyright © 2018 CancerConnect Last updated 01/05.
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