BEVYXXA® - Frequently Asked Questions About BEVYXXA® (betrixaban)

Understand the administration, side effects and answers to frequently asked questions about BEVYXXA® (betrixaban)

Trade Name: BEVYXXA®

Generic Name: betrixaban

For which conditions is BEVYXXA® approved for? BEVYXXA is indicated for the prevention of venous thromboembolism (VTE) in adults who are hospitalized for an acute illness and are have risk factors for VTE. VTE is a blood clot in a vein. The BEVYXXA labeling contains a boxed warning to alert healthcare professional and patients about the potential severe side effect of epidural or spinal hematomas which may result in permanent paralysis and should be considered when scheduling patients for spinal procedures.

What is the mechanism of action of BEVYXXA®? BEVYXXA is a factor Xa (FXa) inhibitor which helps prevent blood clotting.

How is BEVYXXA typically given (administered)? BEVYXXA is taken orally, once per day at the same time each day with food. If a dose is missed, talk to your doctor.

How are patients typically monitored? During treatment with BEVYXXA, at a minimum your healthcare provider will do blood tests to check your blood counts before you start treatment and at least every two weeks for the first 3 months during treatment to check for side effects.

What are the common (occur in 20% or more of patients) side effects of treatment with BEVYXXA?

  • Bleeding
  • Bruising

This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.

Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.

What can patients do to help alleviate or prevent discomfort and side effects of BEVYXXA®?

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. BEVYXXA and certain other medicines may affect each other. Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.

Are there any special precautions patients should be aware of before starting treatment?

Tell your doctor about all of your medical conditions, particularly if you have pathological bleeding or kidney impairment. Avoid using BEVYXXA if you are taking another anticoagulant. Tell your physicians or dentist that you are taking BEVYXXA prior to any surgical, medical or dental procedure and before any new drug is taken. If you are having a spinal procedure while on BEVYXXA, discuss the sign and symptoms of spinal or epidural hematomas. If you are pregnant, plant to become pregnant or are breastfeeding, talk to your doctor about the risks and benefits of BEVYXXA.

When should patients notify their physician? Tell your doctor if you experience any side effects that bother you or don’t go away. If you have had a spinal procedure while on BEVYXXA, let your doctor know immediately if you experience numbness or weakness of the legs, or bowel or bladder dysfunction.

What is a package insert?

A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.

Last updated: 3/2019

Important Limitations of Use

The information provided above on the drug you have selected is provided for your information only and is not a substitute for consultation with an appropriate medical doctor. We are providing this information solely as a courtesy and, as such, it is in no way a recommendation as to the safety, efficacy or appropriateness of any particular drug, regimen, dosing schedule for any particular cancer, condition or patient nor is it in any way to be considered medical advice. Patients should discuss the appropriateness of a particular drug or chemotherapy regimen with their physician.

As with any printed reference, the use of particular drugs, regimens and drug dosages may become out-of-date over time, since new information may have been published and become generally accepted after the latest update to this printed information. Please keep in mind that health care professionals are fully responsible for practicing within current standards, avoiding use of outdated regimens, employing good clinical judgment kin selecting drugs and/or regimens, in calculating doses for individual patients, and verifying all dosage calculations.

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The prescribing physician is solely responsible for making all decisions relating to appropriate patient care including, but not limited to, drugs, regimens, dose, schedule, and any supportive care.

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