Skip to main content

by Dr. C.H. Weaver M.D. 12/2019

Combination strategies of PD-1/PD-L1 inhibition with anti-angiogenic therapy have the potential for improved anti-cancer activity and represent a potential therapeutic opportunity for the treatment of advanced ovarian cancer.

In order to evaluate this approach doctors at Dana Farber Cancer Institute in Boston performed a small single-arm clinical trial of 38 patients with relapsed epithelial ovarian cancer to assess the effectiveness of Opdivo (nivolumab) plus Avastin (bevacizumab) therapy in recurrent ovarian cancer.

Patients were eligible for inclusion in the trial if they had been given 1 to 3 previous lines of therapy and had disease recurrence within 12 months of their last platinum-based therapy. Of these patients, 18 had platinum-resistant disease and 20 had platinum-sensitive disease.

Overall the combination therapy with Opdivo-Avastin was generally well tolerated and led to response rates of 40% and 17% in patients with platinum-sensitive and platinum-resistant disease. The average duration of survival without ovarian cancer progression was 8.1 months.

Scroll to Continue

Recommended Articles

shutterstock_2087020123

Cancer’s Glamour Girl

Diagnosed with CML at 23 Erin Ruddy shares her journey.

shutterstock_2069391023

Jonna's Body, Please Hold

Actress, playwright, and three-time cancer survivor Jonna Tamases celebrates life from center stage.

274864752_633879297819598_1001345989349798990_n

Neulasta Treatment of Neutropenia Improves Treatment

Understand the role of Neulasta treatment of Neutropenia to prevent infection and improve chemotherapy treatment.

The Opdivo-Avastin combination represents another treatment option for patients with relapsed ovarian cancer and appears to have greater activity in the platinum-sensitive setting.

Reference:JAMA Oncol. 2019 Oct 10. Epub ahead of print.