Celiac Disease Associated with Higher Risk of Lymphoma

Cancer Connect

Celiac Disease Associated with Higher Risk of Lymphoma

by Dr. C.H. Weaver M.D. Medical Editor: updated 9/7/2018

Individuals with celiac disease appear to be at increased risk of lymphoma, particularly if they have a condition known as persistent villous atrophy, according to the results of a large cohort study published in the Annals of Internal Medicine.[1]

Celiac disease is considered a disease of the digestive system as well as an autoimmune disease. Celiac disease is characterized by intolerance to gluten, which is a protein found in some grains, such as wheat, rye, barley, and triticale. It causes damage to the small intestine, which interferes with the absorption of nutrients from food and triggers an abnormal immune response to foods containing gluten. Celiac disease affects the villi, which are tiny, fingerlike protrusions that line the small intestine and are supposed to allow nutrients from food to be absorbed into the bloodstream. In celiac disease, the villi are damagedand ultimately this damage can result in a condition called villous atrophy, which refers to the erosion of the villi.

The disease affects people worldwide, including more than 2 million people in the United States and its important to know that gluten may also be present in products such as medicines, vitamins, lip balms, and many processed foods. Because people who have celiac disease cannot tolerate gluten, its very important that they learn to carefully read labels and identify foods that may contain gluten. Learn all about celiac disease here

Previous research has indicated that celiac disease might be associated with an increased risk of lymphoma, but the reasons for this association are unclear.[2] Some researchers speculate that it could be related to persistent villous atrophyespecially among people with celiac disease who continue to eat gluten.

In one large study of 7,625 patients with biopsy-confirmed celiac disease 43 percent of patients had evidence of persistent villous atrophy on a second biopsy and 53 patients were ultimately diagnosed with a lymphoma.

The incidence rate of lymphoma was higher among patients with persistent villous atrophy67.9 per 100,000 patient years in the overall group, compared with 102.4 per 100,000 in those with persistent villous atrophy. Even after adjusting for age, sex, education, and duration of disease, the risk of lymphoma was higher among those with ongoing villous atrophy compared with those who had healing of the intestinal mucosa.

Among patients with persistent villous atrophy, the higher risk was most pronounced during the first 12 months after the follow-up biopsy and continued to decline over time. The researchers speculated that these patients may experience a gradual healing process and future biopsies could indicate mucosal healing.

Persistent villous atrophy was associated with a higher risk of non-Hodgkins lymphoma (NHL), unspecified NHL, and T-cell lymphoma.

The researchers concluded that in patients with celiac disease, follow-up biopsy that indicates persistent villous atrophy may be associated with an increased risk for lymphoma. As such, follow-up biopsy could be a useful tool in identifying patients at risk for subsequent lymphoma.


[1] Lebwohl B, Granath F, Ekbom A, et al. Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: A population-based cohort study. Annals of Internal Medicine. 2013;159(3):169-175.

[2] Catassi C, Fabiani E, Corrao G, et al. Risk of non-hodgkin lymphoma in celiac disease. JAMA. 2002; 287(11):1413-9.

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