Patients with Solitary Plasmacytoma May Not Benefit from Initial Chemotherapy

Cancer Connect

Initial treatment options for patients with solitary plasmacytoma include radiation alone or the combination of chemotherapy and radiation. A recent study published in the journal

Blood indicates that treatment with chemotherapy for patients with solitary plasmacytoma should be delayed until the detectable progression of cancer and/or further symptoms of the cancer are exhibited in the patient.

Multiple myeloma is a cancer involving important immune (infection fighting) cells called plasma cells. Plasma cells aid the body in fighting infection by producing specialized proteins, called antibodies, which have the ability to target and/or kill foreign cells. In multiple myeloma, cancerous plasma cells produce abnormal and excessive antibodies that do not have the ability to properly fight infection. In addition, the cancerous plasma cells accumulate in the bone marrow suppressing the normal formation and function of other cells that are necessary for normal production of blood cells and immune functions. Ultimately, the excessive accumulation of cancer cells in the bone marrow leads to the formation of tumors in the bone, called plasmocytomas, causing the bone to break down. Solitary plasmacytoma is the existence of a solitary cancerous tumor in the bone with no detectable myeloma cells elsewhere in the body.

Diagnosis of multiple myeloma includes the detection of proteins produced by the cancer cells, called M-proteins, which can be found in the blood or urine of persons with this cancer. Following diagnosis and/or treatment of multiple myeloma, measurements of M-protein levels, in addition to other medical tests, may be used to continually monitor the status of the cancer and how it responds to certain treatments. There has been controversy regarding the use of chemotherapy for initial treatment in patients with solitary plasmacytoma versus delaying chemotherapy treatment until the cancer progresses. There are two main reasons to delay chemotherapy treatment: 1) early exposure to a chemotherapy drug potentially creates cancer cells that are resistant to the effects of that drug, restricting treatment options later in the disease when it may be more useful; 2) exposure to chemotherapy can induce the development of second cancers later in a patients life.

Researchers at the MD Anderson Cancer Center recently evaluated the outcomes of over 125 patients with solitary plasmacytomas receiving only radiation therapy as initial treatment. Radiation controlled the local plasmacytoma in over 90% of the patients. Cancer recurrences occurred in only 20% of patients who showed a disappearance of M-protein following treatment with radiation. Patients who did not show a decrease in M-protein levels following radiation therapy had a 60% chance of recurrence. This data was compared to other studies evaluating the outcome of patients with solitary plastmacytoma who received both chemotherapy and radiation as initial treatment. The addition of chemotherapy to radiation therapy showed no overall benefit regarding the rate of cancer progression. However, the treatment of chemotherapy did show a delay to cancer progression in a minority of patients.

The results from this study indicate that the addition of chemotherapy to radiation therapy showed no benefit in decreasing the overall chance of cancer progression for patients with solitary plasmacytoma. The role of initial chemotherapy treatment has not yet been definitively determined and further clinical trials are needed to distinguish which patients may benefit from more aggressive initial treatment including chemotherapy and which patients should be spared from unneeded treatment and its associated side effects. Persons with solitary plasmacytoma may wish to speak with their physician about the risks and benefits of initial treatment including chemotherapy or about the participation in a clinical trial further evaluating chemotherapy or other promising new treatment strategies. (Blood, Vol 96, No 6, pp 2037-2044, 2000)

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Multiple Myeloma