by Dr. C.H. Weaver M.D. updated 9/2021
The US Food and Drug Administration has approved Opdivo (nivolumab) in combination with Yervoy (ipilimumab) for first-line treatment of adults with unresectable malignant pleural mesothelioma. This is the first FDA approval for mesothelioma in 16 years.1
The FDA approval was based on the results from the checkmate 743 clinical trial that directly compared the Opdivo - Yervoy combination administered for up to two years to standard platinum-doublet chemotherapy for up to six cycles in 605 patients.
Patients who received the combination had an average overall survival duration of 18.1 months compared to 14.1 months for chemotherapy.
Follow up data was released in Sept, 2021 - minimum follow-up of three years
- 23% of Opdivo - Yervoy treated patients were alive at three years, compared to 15% of patients treated with chemotherapy.
PD-1 Checkpoint Inhibitors
Opdivo is a type of immunotherapy called a Checkpoint inhibitor that helps to restore the body’s immune system in fighting cancer by releasing checkpoints that cancer uses to shut down the immune system. PD-1 and PD -L1 are proteins that inhibit certain types of immune responses, allowing cancer cells to evade an attack by the body’s immune cells. Checkpoint inhibitor drugs that block the PD-1 pathway enhance the ability of the immune system to fight cancer. By blocking the binding of the PD-L1 ligand these drugs restore an immune cells’ ability to recognize and fight the lung cancer cells.
Keytruda (pembrolizumab) is another checkpoint inhibitor used to treat other forms of cancer, can be effective in the treatment of the most common form of mesothelioma, according to a new study led by investigators from the Perelman School of Medicine at the University of Pennsylvania. The study, published in The Lancet Oncology, is the first to show a positive impact from checkpoint inhibitor immunotherapy drugs on this disease.2
Malignant pleural mesothelioma is a rare and aggressive cancer that represents about 90 percent of all malignant mesothelioma cases. It’s primarily caused by the inhalation of asbestos, a fiber commonly found in some forms of insulation, vinyl floor tiles, and other material. Tumors form in the pleura, a thin membrane of cells that line the lungs and chest wall. Most patients survive less than a year. This poor prognosis is partially due to the fact that most patients are not diagnosed until they are already at a late stage of the disease. The standard first-line therapy treatment involves chemotherapy, and currently there is no approved second-line therapy.
“There have been a lot of studies looking at different drugs, but researchers have not seen positive results,” said the study’s lead author Evan Alley, MD, PhD, chief of Hematology and Medical Oncology at Penn Presbyterian Hospital. “But we’ve found this new class of drugs, checkpoint inhibitors, seems to be more effective than what’s been available in the past.”
Checkpoint inhibitors are a class of drugs designed to free the body’s immune system to fight back against cancer. Keytruda, in particular, has been used to treat melanoma, non-small cell lung cancer, and in some cases, head and neck cancers.
Alley and his team presented data from an ongoing trial involving 13 different research sites in six different countries all looking at the effect of Keytruda on patients with advanced malignancies, including malignant pleural mesothelioma. The study evaluated 25 patients with pleural mesothelioma, all of whom were over the age of 18 and had either already been treated with chemotherapy or were unable to receive it. Patients who had already received another checkpoint inhibitor were not included in the study.
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Beginning with the first enrollees two years ago, doctors gave each patient a dose of Keytruda every two weeks. The tumor reduced in size in 14 of those patients. On average, patients went about six months without their disease progressing, and overall survival was about 18 months. Fourteen patients passed away during the study, while four were still undergoing treatment as of the study’s writing.
“Most patients who receive a second-line therapy have a life expectancy of about six or seven months, so to have four patients still ongoing at two years is very encouraging,” Alley said.
The most common side-effects reported were fatigue, nausea, loss of appetite, and dry mouth.
“One great sign in this study is that none of the patients had to stop treatment because of side-effects,” Alley said. “Some had temporary stoppages, but they were able to continue. The drug appears to be well-tolerated.”
There are multiple studies going on right now to confirm these findings, which the authors note is a necessary step before the drug can become a standard second-line therapy.
“This study provides evidence that some patients can have long-term disease control with this drug, which we haven’t seen before,” Alley said. “We need to better understand what we can do next to make immunotherapy more effective for more patients.”
Alley said there are already plans for trials that will test combination therapies, which will utilize Keytruda in conjunction with other treatments. Those studies are expected to launch later this year, including two at Penn.
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- US Food and Drug Administration. FDA Approves Drug Combination for Treating Mesothelioma. October 2, 2020. https://www.fda.gov/news-events/press-announcements/fda-approves-drug-combination-treating-mesothelioma. Accessed October 5, 2020.