Spindle Cell Melanoma
by Dr. C. H. Weaver M.D. 6/2020
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Spindle cell melanoma is a rare subtype of melanoma, which is relatively uncharacterized, but most commonly occurs in caucasian people of 60~80 years of age with a predominance in males. The exact cause of spindle cell melanoma is unknown. Spindle cell melanoma shares some common mutations with conventional melanomas and all patients should undergo genomic biomarker NGS testing in order to determine if there is a cancer driving mutation that can be treated with a precision cancer medicine. (1-5)
- Approximately 30% of spindle cell melanomas contain BRAF mutations; the V600E substitution mutation is the most common.
- NRAS and KIT mutations are rarely seen.
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