Spindle Cell Melanoma
by Dr. C. H. Weaver M.D. 6/2020
Spindle cell melanoma is a rare subtype of melanoma, which is relatively uncharacterized, but most commonly occurs in caucasian people of 60~80 years of age with a predominance in males. The exact cause of spindle cell melanoma is unknown. Spindle cell melanoma shares some common mutations with conventional melanomas and all patients should undergo genomic biomarker NGS testing in order to determine if there is a cancer driving mutation that can be treated with a precision cancer medicine. (1-5)
- Approximately 30% of spindle cell melanomas contain BRAF mutations; the V600E substitution mutation is the most common.
- NRAS and KIT mutations are rarely seen.
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Spindle cell melanoma: Incidence and survival, 1973-2017
Spindle cell melanoma (SCM) is a rare morphological subtype of melanoma, which is relatively uncharacterized. The aim of the present study was to investigate the incidence of SCM, its general demographics, basic clinico-pathologic features, treatment ...