Imfinzi Treatment for Stage III NSCLC Reduces Recurrence & Prolongs Survival

Imfinzi immunotherapy becomes standard treatment for stage III NSCLC - decreases progression and prolongs survival.

by Dr. C.H. Weaver M.D. 2/2018

The US Food and Drug Administration (FDA) approved Imfinzi (durvalumab) for the treatment of patients with stage III non-small cell lung cancer (NSCLC) whose cancer is unresectable and has not progressed after chemoradiation based on results from the "Pacific" clinical trial because the addition of Imfinizi to chemoradiation further delayed cancer progression and prolonged survival. (2,3)

About Stage III NSCLC

Stage III NSCLC represents approximately one third of NSCLC’s and was estimated to affect around 100,000 individuals worldwide.(1) About half of these patients have cancers that cannot be removed by surgery. For patients with stage III lung cancer that cannot be removed surgically, the current standard treatment is chemoradiation. Although a small number of patients may be cured with the chemoradiation, the cancer will typically progress. New treatment approaches are needed in order to improved the outcome of these individuals.

About Imfinzi

Imfinzi is an investigational human monoclonal antibody directed against programmed death ligand-1 (PD-L1). PD-L1 can be expressed by tumors to evade detection by the immune system through binding to PD-1 on cytotoxic T lymphocytes. Imfinzi blocks the PD-L1 interaction with PD-1, countering the tumor’s immune-evading tactics. Imfinzi is being developed, alongside other immunotherapies, to empower the patient’s immune system and attack the cancer. Imfinzi is already FDA approved for certain patients with locally advanced or metastatic bladder cancer.

About PACIFIC Clinical Trial

The PACIFIC clinical evaluated Imfinzi as sequential treatment in patients with locally-advanced, unresectable, stage III NSCLC. Patients received placebo or sequential treatment with Imfinzi for up to 12 months if they had not progressed following standard platinum-based chemotherapy concurrent with radiation.(2,3)

The new approval in NSCLC was based on these results from the multicentre PACIFIC trial, in which all of the patients with stage IIIA NSCLC that had non progressive cancer after chemoradiation were treated with either with Imfinzi or a placebo and directly compared. Imfinzi was initially reported to significantly delay the time to cancer progression compared with placebo. Imfinzi treated patients survived on average 16.8 months without cancer progression compared to only 5.6 months for those treated with placebo. Trial results were updated in May 2019; overall 57% of Imfinzi treated patients survived 3 years from treatment compared to 44% of those treated with chemoradiation without Imfinzi. Imfinai reduced the risk of dying from stage IIIA NSCLC by 32%. (3)

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