High incidence of ROS 1 false negative tests reported by U Colorado researchers. http://www…
High incidence of ROS 1 false negative tests reported by U Colorado researchers.
Is your lung cancer really ROS1-negative? Study shows it may be worth testing again - Colorado Cancer Blogs
Drugs like crizotinib are used to treat patients with ROS1-positive lung cancer. But which patients are ROS1-positive? A University of Colorado Cancer Center study published in the Journal of Thoracic Oncology shows that common laboratory tests used to determine ROS1 status all have inherent limitations that can lead to false-negative results. Some samples that were determined to be ROS1-negative by one test were shown to be ROS1-positive by another, meaning that some patients who could benefit from ROS1-directed therapy may be slipping through the cracks.