Delay in Radiation Therapy Increases Risk of Breast Cancer Recurrence

Delay in Radiation Therapy Increases Risk of Breast Cancer Recurrence

Among older women who undergo breast-conserving surgery (lumpectomy) for early breast cancer, a longer interval between surgery and the start of radiation therapy increases the risk of local cancer recurrence. These results were published in the British Medical Journal.

Surgery for early-stage breast cancer involves either a mastectomy or a lumpectomy. A mastectomyinvolves removal of the entire breast, whereas a lumpectomy involves removal of the cancer and some surrounding tissue. Because a lumpectomy alone is associated with a higher rate of cancer recurrence than mastectomy, patients who elect to have a lumpectomy are also treated with radiation therapy. The combination of lumpectomy and radiation is referred to as breast-conserving therapy. Breast-conserving therapy and mastectomy produce similar rates of long-term survival.

Among women who undergo breast-conserving therapy, prompt treatment with radiation therapy after surgery may result in better outcomes than delayed radiation therapy. To explore this issue, researchers evaluated information from a large U.S. database that links cancer registry data with Medicare claims data. Information was available for more than 18,000 women over the age of 65 who had undergone breast-conserving therapy for Stage 0-II breast cancer. The study was restricted to women who did not receive chemotherapy.

The primary outcome of interest was the rate of local cancer recurrence (cancer recurrence within the breast).

The median time from surgery to start of radiation therapy was 34 days. Thirty percent of women started radiation therapy more than six weeks after surgery.

  • Longer intervals between surgery and the start of radiation therapy were linked with an increased risk of local cancer recurrence. For example, women who started radiation therapy more than six weeks after surgery were 19% more likely to experience local cancer recurrence than women who had a shorter interval between surgery and radiation.
  • Women were more likely to have a longer interval between surgery and the start of radiation therapy if they had positive lymph nodes, other health conditions, a history of low income, or were of Hispanic ethnicity or non-White race. Longer intervals were also more common in regions of the United States that had higher rates of breast-conserving therapy, suggesting that busy treatment facilities may have longer wait times.

These results suggest that starting radiation therapy as soon as possible after lumpectomy may reduce the risk of local cancer recurrence.

Reference: Punglia RS, Saito AM, Neville BA, Earle CC, Weeks JC. Impact of interval from breast conserving surgery to radiotherapy on local recurrence in older women with breast cancer: retrospective cohort analysis. British Medical Journal [early online publication]. March 2, 2010.

Copyright © 2018 CancerConnect. All Rights Reserved.

Comments (3)
No. 1-3
Jack0147
Jack0147

I haven't seen a man that is more powerful and has fast/effective medication than Dr Korofo in terms of herbal medication and spell casting. My mother has being suffering from breast Cancer for many years now and after all the medication from different herbal Drs and hospital/pharmacy, Dr Korofo was the only Dr that was able to cure and made my mom healthy. We only met Dr Korofo on Instagram and I contacted him for help and that was how he solved our problems after explaining my moms condition to him. Dr Korofo is ready to help anyone suffering from any type of Cancer or any diseases at all such as HIV, herpes, Hepatitis B and C, Fibroid, Seizure's, ALS, Alzheimer's, kidney problem, Vitiligo, Liver problem, Diabetes and many more. You can get in touch with him through the following contact info if you need his help in any way Dr korofo help: Email: greatkorofosolutionhome@yahoo.com Facebook page: https://web.facebook.com/A-place-where-you-can-get-your-problems-solved-no-matter-the-situation-659772167547824/ Thank you the Great Korofo I and my entire family will forever be grateful to you for saving our mom.

mary john
mary john

ALL THANKS TO DR OSO WITH HIS HERBAL PORTION I WAS COMPLETELY CURED FROM BREAST CANCER. I'm here again to appreciate. DR OSO God will always continue to bless you more abundantly, for the good works you don in my life, I will always keep on writing good and posting my testimonies about you on the Internet, I’m MARY JOHNSON from TEXAS . I was tested breast cancer positive, I saw a blog on how DR OSO cured people with his herbal portion, i did not believe in natural medicine but i just decided to give him a try, I contacted him,and explain my situation to him,few day later he sent me the herb, after taking DR OSO herbal medicine for few weeks i went to hospital for check up so luckily i was healed with his herbal portion, i am so happy. If you have any type of cancer problem or you are also infected with any kind of disease, contact him drosohaberhome@gmail.com or call/whatapp +2348162084839 for advice and for his product,i hope this testimony also help some one out there ..

         here is the  dr website.

His blog page https://drosohaberhome.blogspot.com

you can also email me for more info about DR oso via maryjohnson9700@gmail.com ALL THANK TO DR OSO .//..,,..,

mary john
mary john

ALL THANKS TO DR OSO WITH HIS HERBAL PORTION I WAS COMPLETELY CURED FROM BREAST CANCER. I'm here again to appreciate. DR OSO God will always continue to bless you more abundantly, for the good works you don in my life, I will always keep on writing good and posting my testimonies about you on the Internet, I’m MARY JOHNSON from TEXAS . I was tested breast cancer positive, I saw a blog on how DR OSO cured people with his herbal portion, i did not believe in natural medicine but i just decided to give him a try, I contacted him,and explain my situation to him,few day later he sent me the herb, after taking DR OSO herbal medicine for few weeks i went to hospital for check up so luckily i was healed with his herbal portion, i am so happy. If you have any type of cancer problem or you are also infected with any kind of disease, contact him drosohaberhome@gmail.com or call/whatapp +2348162084839 for advice and for his product,i hope this testimony also help some one out there ..

         here is the  dr website.

His blog page https://drosohaberhome.blogspot.com

you can also email me for more info about DR oso via maryjohnson9700@gmail.com ALL THANK TO DR OSO ....//...