Xermelo™

Class: Supportive Care

Generic Name: telotristat ethyl

Trade Name: Xermelo™

For which conditions is this drug approved? Telotristat ethyl is approved to be used in combination with somatostatin analog (SSA) therapy for the treatment of adults with carcinoid syndrome diarrhea.

What is the mechanism of action?  Carcinoid syndrome is a cluster of symptoms that occurs in patients with advanced neuroendocrine tumors (NET) which results in diarrhea from the overproduction of serotonin by these tumors. Telotristat ethyl works by inhibiting certain enzymes that produce serotonin, thereby reducing the rate of serotonin production.

How is telotristat ethyl typically given? Telotristat ethyl is taken orally (by mouth) in the form of a tablet.

What are the most common side effects of treatment with telotristat ethyl?

  • Nausea
  • Headache
  • Increased GGT
  • Depression
  • Gas
  • Decreased appetite
  • Swelling in legs or arms
  • Weight loss

This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.

Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.

 What should patients be aware of before or during treatment of telotristat ethyl?

  • Telotristat ethyl reduces bowel movement frequency. Discontinue telotristat ethyl if severe constipation or abdominal pain develops.

Last updated on 03/17.

What is a package insert?

A package insert is required by the FDA and contains a summary of the essential scientific information needed for the safe and effective use of the drug for healthcare providers and consumers. A package insert typically includes information regarding specific indications, administration schedules, dosing, side effects, contraindications, results from some clinical trials, chemical structure, pharmacokinetics and metabolism of the specific drug. By carefully reviewing the package insert, you will get the most complete and current information about how to safely use this drug. If you do not have the package insert for the drug you are using, your pharmacist or physician may be able to provide you with a copy.

Important Limitations of Use

The information provided above on the drug you have selected is provided for your information only and is not a substitute for consultation with an appropriate medical doctor. We are providing this information solely as a courtesy and, as such, it is in no way a recommendation as to the safety, efficacy or appropriateness of any particular drug, regimen, dosing schedule for any particular cancer, condition, or patient nor is it in any way to be considered medical advice. Patients should discuss the appropriateness of a particular drug or chemotherapy regimen with their physician.

As with any printed reference, the use of particular drugs, regimens and drug dosages may become out-of-date over time, since new information may have been published and become generally accepted after the latest update to this printed information. Please keep in mind that health care professionals are fully responsible for practicing within current standards, avoiding use of outdated regimens, employing good clinical judgment in selecting drugs and/or regimens, in calculating doses for individual patients, and verifying all dosage calculations.

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The prescribing physician is solely responsible for making all decisions relating to appropriate patient care including, but not limited to, drugs, regimens, dose, schedule, and any supportive care.

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