Melanoma Information Center
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An Independent Data Monitoring Committee recently recommended that a clinical study of the combination treatment Mekinist™ plus Tafinlar™ versus Zelboraf® (vemurafenib) for metastatic cutaneous melanoma patients be stopped early so that those receiving Zelboraf could cross over and begin taking the combination therapy instead. Trial Evaluating Nivolumab in Advanced Melanoma Halted Early Because of Superior Results
A clinical trial evaluating cancer immunotherapy nivolumab, which is being developed in advanced melanoma, was halted early after it was determined that the drug was likely to prolong survival. Enzyme Inhibitor Is Well Tolerated and Shows Tumor Response in Melanoma
Researchers determined a dosing level of indoleamine 2,3-dioxygenase 1 inhibitor combined with Yervoy that was well tolerated in metastatic melanoma patients and showed promising tumor response and duration of response.
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Melanoma Clinical Trials
VicalLX01-315-02 – A Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of Treatment with 2 mg Intralesional Allovectin-7 Compared to Dacarbazine (DTIC) or Temozolomide (TMZ) in Subjects with Recurrent Metastatic Melanoma
COGE1697 – Phase III Randomized Study of Four Weeks High Dose IFN 2b in Stage T3-T4 or N1 (microscopic) Melanoma
ECOGE1697 – Phase III Randomized Study of Four Weeks High Dose IFN-a2b in Stage T2b No, T3a-bNo, T4a-b No, and T1-2, N1a, 2a (microscopic) Melanoma.