Signs and Symptoms

of Carcinoma of Unknown Primary

The signs and symptoms of CUP are different, depending on where the cancer has spread in the body.  Signs and symptoms may be caused by CUP or by other conditions. Check with your doctor if you have any of the following:

  • Lump or thickening in any part of the body.
  • Fever for no known reason that does not go away.
  • Night sweats.
  • Unexplained weight loss.
  • Pain that is in one part of the body and does not go away.
  • A cough that does not go away or hoarseness in the voice.
  • Change in bowel or bladder habits, such as constipation, diarrhea, or increased frequency of urination.
  • Unusual bleeding or discharge.

Next: Diagnosis & Tests for CUP


Stella, GM; Senetta, R; Cassenti, A; Ronco, M; Cassoni, P (24 January 2012). “Cancers of unknown primary origin: current perspectives and future therapeutic strategies”. Journal of translational medicine. 10: 12.

National Institute for Health and Clinical Excellence. Clinical guideline 104: Metastatic malignant disease of unknown primary origin. London, 2010.