Class: Supportive Care
Generic Name: telotristat ethyl
Trade Name: Xermelo™
For which conditions is this drug approved? Telotristat ethyl is approved to be used in combination with somatostatin analog (SSA) therapy for the treatment of adults with carcinoid syndrome diarrhea.
What is the mechanism of action? Carcinoid syndrome is a cluster of symptoms that occurs in patients with advanced neuroendocrine tumors (NET) which results in diarrhea from the overproduction of serotonin by these tumors. Telotristat ethyl works by inhibiting certain enzymes that produce serotonin, thereby reducing the rate of serotonin production.
How is telotristat ethyl typically given? Telotristat ethyl is taken orally (by mouth) in the form of a tablet.
What are the most common side effects of treatment with telotristat ethyl?
- Increased GGT
- Decreased appetite
- Swelling in legs or arms
- Weight loss
This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.
Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome.
What should patients be aware of before or during treatment of telotristat ethyl?
- Telotristat ethyl reduces bowel movement frequency. Discontinue telotristat ethyl if severe constipation or abdominal pain develops.
Last updated on 03/17.
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